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AN EFFECT OF XYLITOL ON THE ADHESIVENESS OF STREPTOCOCCUS MUTANS TO SYNTHETIC HYDROXYAPATITE

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Abstract

ÇöÀç Ä¡°ú°è¿¡¼­ °¡Àå È¿°ú¸¦ ÀÎÁ¤¹Þ´Â ´ëü °¨¹Ì·á·Î ÀÚÀϸ®ÅçÀÌ ÀÖÀ¸¸ç, ÃÖ±Ù °ü·Ã»óÇ°ÀÌ Áõ°¡ ÇÏ°í ÀÖ´Ù. ÇÏÁö¸¸ ¸¹Àº °ü·Ã »óÇ°Àº Á¦Ç°¿¡¼­ ÀÚ´çÀÌ Â÷ÁöÇÏ´Â ºÎºÐ ¸ðµÎ¸¦ ÀÚÀϸ®Åç·Î ´ëüÇÏÁö ¸øÇÏ°í ºÎºÐ´ëÄ¡ÇÏ°í Àֱ⠶§¹®¿¡ ÀÚ´ç Á¸ÀçÇÏÀÇ Á¶°Ç¿¡¼­ ÀÚÀϸ®ÅçÀÇ Ç׿ì½Ä ÀÛ¿ëÀÌ ÀÓ»óÀûÀ¸·Î ´õ Áß¿äÇÏ´Ù°í ÇÒ ¼ö ÀÖ´Ù.
º» ¿¬±¸ÀÇ ¸ñÀûÀº ÀÚ´ç°ú ÀÚÀϸ®ÅçÀÇ ´Ù¾çÇÑ ³óµµºñÀÇ Á¶°Ç¿¡¼­ ÀÚÀϸ®ÅçÀÇ Ç׿ì½Ä ÀÛ¿ëÀÇ Á¤µµ¸¦ ±Ô¸íÇÏ°íÀÚ ÇÔÀ̸ç ÀÚ´ç°ú ÀÚÀϸ®ÅçÀÇ ³óµµºñ¸¦ ´Þ¸®ÇÑ °¢ ½ÇÇè¿ë¾×¿¡¼­ S. mutansÀÇ ÇÕ¼º¼ö»êÈ­ÀÎȸ¼®¿¡ ´ëÇÑ ºÎÂø´É°ú Ä¡¾Æ¹Ì¼¼°æµµ º¯È­·®À» ÃøÁ¤ÇÏ¿´À¸¸ç ¾Æ·¡¿Í °°Àº °á°ú¸¦ ¾ò¾ú´Ù.
1. ÀÚ´ç°ú ÀÚÀϸ®ÅçÀÇ È¥Çսà ¹èÁö¿¡ Àڴ縸À» Ãß°¡ÇÑ ´ëÁ¶±º¿¡ ºñÇØ S. mutansÀÇ ÇÕ¼º¼ö»êÈ­ÀÎȸ¼® ÀÔÀÚ Ç¥¸é¿¡ ´ëÇÑ ºÎÂøÀ» À¯ÀÇÇÏ°Ô °¨¼Ò½Ãų ¼ö ÀÖ´Â ÀÚÀϸ®ÅçÀÇ ÃÖ¼Ò ºÎÂø¾ïÁ¦ ³óµµºñ´Â ÀÚ´ç°ú ÀÚÀϸ®ÅçÀÌ 25:75 À̾ú´Ù(P<0.05).
2. ¹ý¶ûÁú ¹Ì¼¼°æµµ ÃøÁ¤ °á°ú Àڴ縸 ÷°¡ÇÑ 1±º¿¡ ºñÇØ ÀÚ´ç°ú ÀÚÀϸ®ÅçÀÌ 50: 50ÀÎ 4±ººÎÅÍ ¹Ì¼¼°æµµ °¨¼ÒÄ¡°¡ À¯ÀÇÇÏ°Ô ÁÙ¾îµé¾ú´Ù(P<0.01).
There have been efforts that inhibit development of dental caries by sugar substitution. But, it is controversial if xylitol has anticariogenic effect in the presence of sucrose. And there are few papers dealing with the combined action of xylitol and sucrose. For the purpose of resolving this controversy, the author investigated the effect of xylitol on enamel demineralization and on adhesiveness of S. mutans to hydroxyapatite in the presence of su¡©crose.
Five experimental solutions were prepared as follows: (S: sucrose, X: xylitol) Group 1: BHI broth Group 2: BHI + 1% S Group 3: BHI + 0.75% S + 0.25% X Group 4: BHI + 0.5% S + 0.5% X
Group 5: BHI + 0.25% S + 0.75% X Group 6: BHI + 1% X
Each solution was inoculated with 100W of S. mutans JC-2. And saliva coated hydroxyapatite beads were put into each experimental solution. And then each solution was incubated at 371C under anaerobic condition. After incubation, the adhesiveness of S. mutans on hydroxyapatite was evaluated. The Vickers hardness numbers were measured on extracted human primary teeth, and these teeth were dipped into the same experimental so¡©lution and incubated at 37 *C under anaerobic condition for 48hours. Surface microhardness were measured again after incubation.
The obtained results were as follows
1. In the presence of sucrose, xylitol can reduce the adhesiveness of S. mutans on hydroxyapatite surface from the ratio of 25% sucrose to 75% xylitol(P ( 0.05).
2. In the presence of sucrose, xylitol can reduced demineralization of primary teeth enamel surface from the ratio of 50% sucrose to 50% xylitol(P C 0.01).

Å°¿öµå

ÀÚÀϸ®Åç;¼¼±Õ ºÎÂø´É;¹Ì¼¼°æµµ;³óµµºñ;Xylitol;Bacterial adhesiveness;Microhardness;Concentration ratio

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